Dynamic measurement of CRP, IL-6 and Fib levels of unstable angina and its clinical significance

Abstract

Objective To study the clinical significance of dynamic determination of serum CRP,IL-6 and fibrinogen(Fib)levels in unstable angina pectoris(UAP) patients. Methods 162 UAP patients were selected as UAP group(including 52 cases of low risk group,53 cases in medium risk group and 57 cases in high risk group),58 healthy people were selected as control group.The CRP,IL-6 and Fib contents were observed in UAP patients after cardiac events. Results At discharge,CRP,IL-6,Fib in UAP low risk group were(3.47± 0.55)mg/L,(10.38±1.57)ng/L,(1.64±0.65)g/L,which were significantly lower than the admission contents [(6.50±0.87)mg/L,(14.35±1.22)ng/L,(3.01±0.28)g/L](t= 2.761,2.945,2.118,P= 0.028,0.003,0.031). CRP,IL-6,Fib levels in the medium risk group were(6.87±0.75)mg/L,(14.35±1.02)ng/L,(2.26±0.33) g/L,which were significantly lower than the admission contents[(9.21±1.03)mg/L,(19.24±1.58)ng/L,(4.15±0.47)g/L](t= 2.985,3.157,3.548,P= 0.003,0.001,0.000).CRP,IL-6,Fib levels in the high risk group were(8.71±0.84)mg/L,(17.37±1.26)ng/L,(4.67±0.85)g/L,which were significantly lower than the admission contents[(12.48±1.24)mg/L,(25.13±1.84)ng/L,(7.28±0.64)g/L](t= 3.472,4.018,5.097,P= 0.000,0.000,0.000).Six months after hospital discharge,in CRP,IL-6,Fib elevated groups,the incidence rates of cardiac event were 40.20%,40.35% and 47.50%,which were significantly higher than those in normal group (5.0%,4.17%,14.29%,χ2= 23.655,2.211,14.442,P= 0.000,0.000,0.000). Conclusion CRP,IL-6 and Fib levels in UAP patients were significantly higher than those in healthy people,and with remission,contents would be lower,which was the index to reflect the severity of UAP,but its specificity is bad,need to use caution. Key words: Angina,unstable; C-reactive protein; Interleukin-6; Fibrinogen