Abstract
Dual contrast CMR for evaluation of telmisartan and amlodipine combination therapy in the diabetic murine myocardial injury model
Highlights
Combination therapy has been shown to improve cardiovascular outcomes in hypertensive, diabetic patients
The mice were allocated to two groups: (1) tap water (n = 17) and (2) addition of telmisartan (10 mg/kg/day) and amlodipine (10 mg/kg/day) in the tap water per os ad libitum following 1 week of convalescence after Acute myocardial injury (AMI) (n = 23)
We demonstrate significantly improved left ventricular function at weeks 1, 2, and 4 following combined telmisartan and amlodipine therapy (32.0% ± 4.8%*, 31.8% ± 3.9%*, and 35.3% ± 2.3%*) compared to control (18.9% ± 1.5%, 21.8% ± 1.3%, and 15.7% ± 3.4%, *p < .05)
Summary
Combination therapy has been shown to improve cardiovascular outcomes in hypertensive, diabetic patients. Amlodipine demonstrates beneficial pleiotropic effects including improved endothelial function, enhanced angiogenesis, and reduced cardiovascular risk. Telmisartan exhibits similar beneficial cardiovascular effects in diabetic patients. Amlodipine in combination with telmisartan may provide a synergistic benefit. Dual contrast CMR, using manganese (manganese-enhanced MRI; MEMRI) and gadolinium (delayed-enhanced MRI; DEMRI), will evaluate the viable myocardium and myocardial scar, respectively, to investigate the underlying mechanism of combined telmisartan and amlodipine therapy
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