Abstract
Objective To analyze the dose of left thyroxine in the treatment of hypothyroidism during pregnancy. Methods 260 cases of pregnant women with hypothyroidism were selected and given left thyroxine treatment.According to pre pregnancy with or without hypothyroidism, they were divided into two groups: group A with hypothyroidism before pregnancy(111cases), and group B without hypothyroidism before pregnancy(149 cases). According to the maternal serum TSH level, adjustment of levothyroxine dose(L-T4 dosage) were observed during the treatment period, and the thyroid stimulating hormone(TSH) levels were detected in different gestational weeks before and after treatment.According to the thyroid etiology all patients were divided into hypothyroidism after 131I therapy, hypothyroidism after thyroiditis, thyroid postoperative hypothyroidism, in order to analyze the different causes of levothyroxine dose. Results The dosages of L-T4 of group A in 3-9 months were significantly higher than those in the beginning (t=7.848, 11.853, 14.730, 16.608, 22.282, 22.630, 23.238, all P 0.05), and in group B 1 month after delivery, the dosages of L-T4 was (28.55±7.13)μg/d, which was significantly lower than (50.34±9.01)μg/d in the beginning(t=23.149, P 0.05). Pregnant women with hypothyroidism, including thyroiditis hypothyroidism, hypothyroidism after 131I treatment, and thyroid postoperative hypothyroidism were increasing along with gestational age increasing, as well as the amount of L-T4.The dosages of L-T4 in 3-9 months after 131I treatment were significantly higher than those in the same month of pregnancy thyroiditis hypothyroidism after pregnant(t=24.491, 27.900, 29.949, 29.666, 31.384, 29.774, 30.195, all P<0.01). After thyroid surgery hypothyroidism pregnant in 3-9 months, the amount of L-T4 was significantly higher than that in the same month of pregnancy thyroiditis hypothyroidism after pregnant women (t=25.007, 27.887, 29.830, 31.568, 30.248, 31.969, 28.033, all P<0.01). Conclusion In patients with hypothyroidism during pregnancy, the amount of L-T4 increases with the gestational age.And the same month of pregnancy with hypothyroidism before pregnancy, the dosage of L-T4 is higher than pregnancy complicated with hypothyroidism, while after thyroid surgery and 131I therapy in patients with hypothyroidism has higher doses of L-T4 treatment. Key words: Pregnancy; Left thyroxine; Hypothyroidism; Dose
Published Version
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