Abstract
Cells undergoing cell division duplicate their chromosomal DNA quickly and faithfully. During the S phase of the cell cycle, DNA replication duplicates a double-stranded molecule of DNA into two daughter molecules. DNA replication occurs at replication forks – structures consisting of DNA and several dozen replication proteins that allow the two strands of DNA to be copied accurately and completely. At the replication forks, one strand of DNA is copied continuously while the other is duplicated in fragments known as Okazaki fragments. This article summarizes the current knowledge of the proteins and complexes acting at the eukaryotic replication fork.
Published Version
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