Abstract
Dividing weight error of powders with an automatic medicine dividing and packing machine (Konishi 727-K10 type) was investigated at the slit gap M (ca. 2.5 mm) and the middle intensity of vibration. When the machine's starting position of effluence of 2g crystalline lactose in 1 package at 21 or 30 divisions was changed, dividing weight error indicated coefficient of varition (C. V.) 4.3-8.8%. The starting position which minimized the dividing weight error was found to be 17 th hole in case of 21 divisions and 20 th hole in case of 30 divisions. Dividing weight of the first 2 packages and the last 2 packages at the turn was significantly lighter than that of other packages. In case of 30 divisions, C. V. of error in dividing weight of 0.5g crystalline lactose in 1 package was about 17%, that of 1. 0g 10%, 2.0g 4%, 3.0 and 4.0g 6%. Dividing weight error of several powders with different physical properties in 2g package at 30 divisions was investigated. C. V. of crystalline lactose was 4.3%, that of lactose fine granule 5.7%, corn starch 9.5%, and synthetic aluminum silicate 13.6%. Powdered lactose was indivisible.
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