Abstract
Some experiments were carried out on the method for evaluation of mixing properties of some medicinal granule preparations, using lactose, crystalline lactose, corn starch, and synthetic aluminium silicate. These medicinal powders (A) were labeled with radionuclide, indium-113 m. Medicinal granule preparations (B) were lactose granules of 100 -200, 65-100, and 42-65 mesh, and commercial pharmaceutical granular preparations of 42-50 (I), 48-100 (II), 20-35 (III), and 28-36 (IV) mesh. Mixing of A and B was carried out with a YMQ-type dispensing mixer, three tines for 5 sec each. Mixing ratio was 1 : 4, 1 : 2, 1 : 1, 2 : 1, and 4 : 1 for A to B. Permitted limit of good mixing properties was decided to be 6.18% of the coefficient of variation of A and B in 10 samples. Experimental results indicated that lactose granules of 100-200 and 65-100 meshes, and I showed good mixing with A in various mixing ratios. Other medicinal granules showed poor mixing with crystalline lactose and synthetic aluminium silicate among A, and showed different mixing ability according to physical properties of B. This method of evaluation is effective for predicting the mixing ability of medicainal granules and general medicinal powders in dispensing.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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