Abstract
Some experiments were carried out on the effect of various additives powders for the improvement of mixing on some medicinal powders and granular preparations in pharmaceutical dispensing. 113mIn was adsorbed on some medicinal powders (A) such as lactose (<74 μ), crystalline lactose (74-149 μ), corn starch, and synthetic aluminium silicate. For granular preparations (B), lactose granules with particle size of 420-590 μ and five kinds of general dispensing granules were used. Mixing ratio was 1 : 2 for A to B in principle. Effect of additive powders was determined from the coefficient of variation in radioactivity of A components using fine crystalline cellulose, dry yeast, fine lactose, and corn starch. Experimental results indicated that crystalline lactose showed a good mixing with lactose granules (420-590 μ) and other medicinal granules by the addition of 5% dried corn starch.
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