Diuretic therapy of chronic heart failure of patients with hypertension in combination with diabetes mellitus type 2

Abstract

The aim of the study was to investigate the xipamide influence on clinical manifestations of chronic heart failure, blood pressure, carbohydrate and lipid metabolism, blood electrolytes, renal function of patients with essential hypertension combined with diabetes mellitus type 2.Materials and methods. 35 patients (19 women and 16 men) with chronic heart failure II–III functional class according to the classification of NYHA in the middle ages (60,6±1,2) years were examined. Heart failure was due to hypertension (average duration was (10,7±6,3) years, hypertension of 2–3 degrees) in combination with diabetes mellitus type 2 (average duration – (9,5±3,2) year). Xipamide was appointed on the background of both diseases basic treatment in the initial dose of 10-20 mg once a day after eating in the morning. The dose was doubled if necessary. For further therapy xipamide was prescribed in maintenance dose 10–20 mg/day. After 3 months clinical profile of carbohydrate and lipid metabolism, renal function were evaluated.Results. The study revealed that xipamide is an effective and safe means of active treatment of patients with chronic heart failure on the background of hypertension combined with diabetes mellitus type 2. It is also effective for patients in the stage of decompensation, as well as maintenance therapy in heart failure stabilization.Conclusions. Xipamide addition to the basic therapy of chronic heart failure can significantly improve clinical and hemodynamic status of patients almost without affecting on the electrolyte composition of blood, lipid and carbohydrate metabolism and renal function.