Distribution of phynotypes of diabetic kidney disease in latent autoimmune diabetes in adults

Abstract

Objective – to determine the prevalence of diabetic kidney disease phenotypes in latent adult autoimmune diabetes compared to other types of diabetes mellitus.Material and methods. A comprehensive examination of 96 patients with chronic kidney disease and diabetes mellitus: 40 (main group) with latent autoimmune diabetes in adults (LADA), 28 - with type 1 diabetes mellitus(T1DM), 28 - with type 2 diabetes mellitus (T2DM) – comparison groups. Complaints, anamnesis, objective examination, the results of general clinical laboratory tests, carbohydrate metabolism, glomerular filtration rate, albuminuria, albumin-creatinine ratio have evaluated.Results. The classical albuminuric phenotype was diagnosed in 7.1% of patients with T1DM, in 10.7% of patients with T2DM and in 13% of patients with LADA, respectively. The proportion of patients with non-albuminuric renal impairment was 85.7% with T1DM, 53.6% with T2DM and 70.4% with LADA. Progressive decline in renal function was found in 7.1% of cases of T1DM, 35.7% of T2DM and 16.7% of LADA.Conclusions. The prevalence of phenotypes of diabetic kidney disease in LADA differs from that in classical types of diabetes, which requires a differential approach to the management of this diabetic complication.