Distribution of Iodine125 Labeled Parathion and the Protective Effect of Dried Banana Peel in Experimental Mice

Abstract

AbstractParathion (PA) one of the organophosphorus pesticides, is widespread in agriculture crops. Several studies reported the detection of this pesticide residue in food at high concentrations. Accordingly, the purpose of this study was to determine the accumulation of iodine [125I] labeled parathion ([125I] PA) in mice organs and to study the protecting reflex of dried banana peel. In this study, two groups of mice were used. Iodine [125I] labeled parathion (10 mg/kg body weight) was applied only to one group of mice. Meanwhile, [125I] PA (10 mg/kg body weight) and dried banana peel (20% were added to the diet) were applied to the other group of mice. The mice were injected by [125I] PA through the tail vein and were given the dried banana peel through the mouth. The mice were kept under observation for 180 min. for monitoring. The result of the first group of mice, which was injected with [125I] PA, only indicated that [125I] PA was distributed primarily in the kidneys (18.6%), liver (18.9%), and intestine (6.11%), after 180 min. In the second group of mice which received both [125I] PA, and dried banana peels, [125I] PA accumulated at a lower percentage in the kidneys (10.2%), liver (5.2%), and intestine (4.67%) after 180 min. These results indicated the decrease of [125I] PA in the liver and kidneys could be due to the effect of dried banana peels, and draw attention to the use of agricultural waste to remove pesticide residues contaminating food and feed.