Abstract
Definition of the malignant transformation event is central to a distinction between neural stem cells and cancer stem cells. In such manner, the descriptive analysis of various tumors such as gliomas would allow for the distinction of genetic injury and probably epigenetic events that transform gene transcription pathways. Hypoxia is a major conditioning influence acting on stem cell niche microenvironments that evolve in terms particularly of micro-vascular dynamics. The incremental involvement of entire fields of cancerization allows for the establishment of permissive conditions of repetitive nature and within the contextual involvement of multiple clones of injured cells that condition, in turn, the stem cell niche. In view of the establishment of progressive malignant change, it is significant to view the cancerization as an integral involvement of both sequential and concurrent events in defining the roles of stem cells and cancer stem cells in terms of a primal process of dedifferentiation beyond simple markers of morphologic transformation.
Highlights
Derivative recombination of various facets in the characterization of gliomas indicates a restricted array of features that would tend to categorize malignant tumors in terms of biology of stem cells and of cancer stem cells
It is in view of parameters of incremental nature that the malignant transformation process is derived from stem-cell attributes of cancerization. miR-145 represses pluripotency of embryonic stem cells and is a tumor suppressor in different cancers [18]
Significant to the biologic derivation of cancer stem cells there evolves a mixture of attributes that are directly related to the onset of the malignant transformation process
Summary
Derivative recombination of various facets in the characterization of gliomas indicates a restricted array of features that would tend to categorize malignant tumors in terms of biology of stem cells and of cancer stem cells. The acquistion of stem-like traits might promote glioma initiation, growth and recurrence [1] The field of stem cell research applies to regenerative medicine [2]. Hierarchical organization of the proliferative and differential attributes of a glioma indicates a strict conformational profile that includes the distribution and further multiple redistributions of profiles of activity of the lesion. It is with a series of sequential steps in accumulative potential that genetic or karyotypic abnormality assumes a prominent idealization of neoplasms beyond complex systems of dysregulation. Human bone marrowderived mesenchymal stem cells inhibit human glioma growth through downregulation of PDGF/PDGFR axis [4]. Particular specificity in the carcinogenesis and further to the upset of the oncogene/suppressor gene equilibrium there would constitute a series of active sites or domains as integrally composed transformational events
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