Abstract
Objectives Normal thyroid function is crucial for adequate maternal and fetal development in pregnancy. There is solid evidence of the pernicious effects of thyroid dysfunction in pregnancy for both mother and fetus. One of these effects is miscarriage and recurrent pregnancy losses. Nevertheless, there is no general agreement on the advisability of screening for thyroid dysfunction in pregnant women, even when there is a previous history of pregnancy loss. This study aimed to determine the prevalence of thyroid dysfunction (including anti-thyroid autoimmunity without abnormal T3/T4/TSH levels) in patients with spontaneous abortion. Subjects and methods T3-T4-TSH-antithyroid antibodies (thyroglobulin and thyroperoxidase) were determined at diagnosis in 132 consecutive women with spontaneous miscarriage. Results Nearly 25% of the patients had undiagnosed and untreated thyroid disturbance. Conclusion The results obtained suggest that the prevalence of thyroid dysfunction in patients with spontaneous miscarriage is higher than previously reported in our environment.
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