Abstract
We present a study of electronic transport in short (12-base-pair) DNA duplexes covalentlybonded (via thiol groups) to two gold electrodes obtained by a mechanically controllablebreak junction (MCJB) technique in dry conditions. A large number of DNA junctionshave been repeatedly formed in order to obtain a conductance histogram thatreveals a peak which corresponds to the conductance of a single DNA molecule. Weobserved that the conductivity of a DNA increases upon increasing the content ofG:C base pairs in the duplex. With our method we are able to obtain a reliablevalue of a single DNA conductance and subsequently measure its current–voltage(I–V) characteristics. In contrast to the electronic transport measurements performed with longDNA sequences (hundreds of base pairs) where the obtained conductance values vary a lotwith environmental conditions, our values obtained for the short DNA sequences areconsistent with the values reported for comparable sequences in aqueous solution.
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