Abstract
mutant mice suffer a congenital hydrocephalus trig-gered by ependyma denudation [1]. The ventricular sur-face in non hydrocephalic newborn mice is lined by theimmature ependyma, which is characterized for beingvimentin (-) and S100β (-), at variance in the adult ani-mals the mature ependyma expresses vimentin and S100 β[2]. On the other hand, in the hydrocephalic mice theependyma begins to denudate on the 12th day of gesta-tion, and at PN8 only some areas of lateral ventricle arestill endowed with ependyma. In parallel, astroglia startsto cover the denuded surface forming a new cell layer, theglial scar, which lines the damaged ventricular surface. Wehave studied the permeability to horseradish peroxidase(HRP) of these four regions at the ventricular wills:mature ependyma, and denuded areas with or withoutglial scar.
Highlights
Hyh mutant mice suffer a congenital hydrocephalus triggered by ependyma denudation [1]
The ventricular surface in non hydrocephalic newborn mice is lined by the immature ependyma, which is characterized for being vimentin (-) and S100β (-), at variance in the adult animals the mature ependyma expresses vimentin and S100β [2]
We have studied the permeability to horseradish peroxidase (HRP) of these four regions at the ventricular wills: mature ependyma, and denuded areas with or without glial scar
Summary
Hyh mutant mice suffer a congenital hydrocephalus triggered by ependyma denudation [1]. The ventricular surface in non hydrocephalic newborn mice is lined by the immature ependyma, which is characterized for being vimentin (-) and S100β (-), at variance in the adult animals the mature ependyma expresses vimentin and S100β [2]. In the hydrocephalic mice the ependyma begins to denudate on the 12th day of gestation, and at PN8 only some areas of lateral ventricle are still endowed with ependyma. Astroglia starts to cover the denuded surface forming a new cell layer, the glial scar, which lines the damaged ventricular surface. We have studied the permeability to horseradish peroxidase (HRP) of these four regions at the ventricular wills: mature ependyma, and denuded areas with or without glial scar
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