Abstract
Research has shown that many cancers have acommon pathophysiological origin and often present with similar symptoms. In terms of Traditional Uighur Medicine (TUM) Hilit (body fluid) theory, abnormal Savda syndrome (ASS) formed by abnormal Hilit is the common phenotype of complex diseases and in particular tumours. Abnormal Savda Munziq (ASMq), one representative of TUM, has been effective in the treatment of cancer since ancient times. Despite the physiopathology of ASS, the relationship between causative factors and the molecular mechanism of ASMq are not fully understood. The current study expanded upon earlier work by integrating traditional diagnostic approaches with others utilizing systems biology technology for the analysis of proteomic (iTRAQ) and metabolomic (1H-NMR) profiles of Uighur Medicine target organ lesion (liver) tumours. The candidate proteins were analyzed by enrichment analysis of the biological process and biomarker filters. Subsequently, 3Omics web-based tools were used to determine the relationships between proteins and appropriate metabolites. ELISA assay and IHC methods were used to verify the proteomic result; the protein von Willebrand factor (vWF) may be the “therapeutic window” of ASMq and biomarkers of ASS. This study is likely to be of great significance for the standardization and modernization of TUM.
Highlights
abnormal Savda syndrome (ASS) malignant tumours was as high as 72%, far higher than for other abnormal fluids[7]
Abnormal Savda-related disease treatments have centered on abnormal Savda Munziq (ASMq), which regulates the abnormal Hilit that causes disease, recovers the Mizaj and balances other Hilits[1,2,3]
We assumed that the pathophysiology of ASS and its related factors are associated with common mechanisms of pathogenesis and carcinogenesis, but the mechanism remain to be elucidated, which will be the key to prevention and treatment
Summary
ASS malignant tumours was as high as 72%, far higher than for other abnormal fluids[7]. We examined the serum proteomic profile of 29 patients with breast, lung and gastric cancer who underwent treatment of abnormal Savda with its unique ASMq prescription and found that 31 and 27 proteins were differentially expressed in ASS cancer patients and in response to treatment[5]. To verify the results of the clinical analysis, in the present study we established an experimental rat ASS hepatocarcinoma (ASS HCC) model in order to verify the previous results and to analyze ASMq related serum protein changes, in order to identify the “therapeutic window” of ASMq, which will be of great significance for standardization and modernization of TUM
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