Differential diagnosis value of borderline ovarian tumor and stage I epithelial ovarian cancer: using MRI combined with tumor markers

Abstract

Objective To explore the value of MRI combined with tumor markers in the differential diagnosis of borderline ovarian tumor(BOT) and stage I epithelial ovarian carcinoma(EOC), increase the rate of preoperative diagnosis. Methods Fifty-six patients with BOT(BOT group) and forty-seven patients with stage I EOC(EOC group) confirmed pathologically underwent tumor markers and MRI examination were selected.The MRI imaging features and tumor markers level were compared between the two groups. Results BOTand EOC group onset age were (39.45±11.83), (44.38±12.44)years old respectively, two groups had statistically significant difference(t=2.05, P 0.05). However, the solid components were larger (76.0±54.9)mm and the septations were thicker (6.2±3.5)mm in EOC group than in BOT group (49.0±47.2)mm, (3.6±3.5)mm(t=-2.642, -3.784, all P 0.05). The serum HE4 levels between BOT group[(86.9±82.2)pmol/L]and EOC group[(166.3±87.1)pmol/L]had statistically significant difference (t=-4.723, P<0.05). MRI prompt tumors maximum diameter and thickness of the separated solid ingredients combined serum HE4 levels to identify two groups of AUC of the tumor and its sensitivity, specificity were 0.820, 72.3%, 80.4%, respectively. Conclusion The features like younger, increased solid components, thickened septum and higher serum HE4 level may be helpful in the differential diagnosis of BOT and stage I EOC. Key words: Ovarian neoplasms; Magnetic resonance imaging; Tumor markers; Diagnosis, differential