Abstract
Introduction: The COVID-19 pandemic has highlighted the importance of vaccination in reducing severe cases and deaths. However, the emergence of new SARS-CoV-2 variants raises concerns about the efficacy and safety of available vaccines, mainly due to the diversity of technological platforms used in their development. Objectives: To elucidate the current knowledge about the main vaccine against COVID-19 and their respective technological platforms, licensed and in the licensing phase. Methods: Systematic review according to the PRISMA statement of articles published from 2020, through the PubMed database. Results: The search resulted in fifty studies, of which twenty-one were included. Clinical trials addressed vaccines that use mRNA platforms (n=4), non-replicant viral vector (n=3), attenuated virus (n=2), inactivated vaccine (n=1), recombinant protein nanoparticles (n=3), vaccine using virus-like particles (n=1), subunit vaccine (n=1), DNA vaccine (n=1). Most of the vaccines showed good tolerability and induced neutralizing antibodies against various variants of SARS-CoV-2. Conclusions: Except for the non-replicant viral vector vaccine, intranasal ChAdOx1 nCoV-19 that did not induce mucosal and systemic immune responses, and the DNA vaccine, which induced only a good cellular response, the other vaccines demonstrated good tolerability and efficacy in inducing immune responses.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call