Abstract
Objective To study the granulocyte colony stimulating factor(G-CSF) and granulocyte macro- phage colony stimulating factor(GM-CSF) in complete remission of acute myeloid leukemia(AML) patients with den- dritic cells (DC) changes in the function and its subsets. Methods 36 cases of complete remission according to AML patients were randomly divided into 3 groups, G group was given G-CSF 200g/d, subcutaneous injection, GM group were given GM-CSF 200g/d, subcutaneous injection, the control group were injected with normal saline. The curative effects were compared. Results The expression of G in group DC, CD83 and CD86 on surface of CD80 were lower than that in GM group and C group ( t = 4.34,5.43,4.54,4.54,5.25,3.54, all P 〈 0. 05 ), GM group, DC expression of CD11 c was higher than that of G group and C group (t = 4.54,4.27, all P 〈 0.05 ). G group and GM group DC in promoting lymphocyte proliferation were higher than those in C group ( t = 4.54,5.64, all P 〈 0.05 ) ; group GM DC to promote the ability of CD4 ~ T lymphocyte proliferation was higher than that of G group ( t -- 3.54, P 〈 0.05 ). ELISA assay,GM group DC secretion of IL-12 than that of group G and C group;group G DC secretion of IL-10 was higher than that of GM group and C group ( t = 3.54.4.23,4.32,3.87, all P 〈 0.05 ). Conclusion G-CSF and GM-CSF can make the complete remission in patients with AML subgroup DC shift, the bias of G-CSF DC2 and certain immuno- suppressive effect,while GM-CSF DC subsets of DC1 and promotes cell immune deviation. Key words: Colony-stimulating factors; T-lymphocyte subsets ; Leukemia, myeloid
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.