Abstract
MSP-1 is a surface membrane protein of Plasmodium falciparum merozoites that interacts with the erythrocyte membrane receptor and therefore it is a protein involved in its recognition by the red globule.The set theory and experimental data have been used to make a mathematical characterization of 79 different MSP-1 protein sequences, by means of the definition of five rules associated with high binding to the red globule receptor.All the high binding and low binding peptides were correctly characterized according to experimental determinations.Studying more proteins involved in the invasion, this methodology could be useful to detect peptides with high binding in the MSP-1 protein and in other proteins in a more objective and reproducible way. Thus, the binding phenomenon can be described starting from mathematical characteristics.
Published Version
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