Abstract
Investigators representing such diverse disciplines as biochemistry, pathology, genetics and environmental toxicology currently employ fish models as routine and reliable bioassay testing systems for the detection of toxins and/or carcinogens in the environment, and more appropriately, as rapid indicators of carcinogenicity. The Japanese medaka, Oryzias latipes, has served as a popular fish model for carcinogenicity studies, many of which have included diethylnitrosamine (DENA), a site specific carcinogen for hepatic neoplasms. One of the more intriguing manifestations of nitrosamine exposure reported for both fish and rats is spongiosis hepatis, a hepatic lesion characterized by multilocular cyst-like complexes. Spongiosis hepatis has not been reported in medaka exposed as embryos to hepatic carcinogens and the single article indicating the presence of such a lesion in adult medaka is limited in cytological descriptions.
Published Version
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