Abstract

Platelet activity is controlled, in part, by cytosolic free ionized calcium concentration ([Ca++]i). Regulation of platelet thromboxane (TX) synthesis may be by regulation of [Ca++]i, which may be affected by the fatty acid (FA) composition of the membranes in which ion transporters reside. Male non-obese Zucker rats were fed diets supplying 30 en% fat, Dietary fat was composed of corn oil and beef tallow to provide 3.0, 4,5, 6,0, or 7,5 enSK linoleic acid, with cholesterol added to provide equal cholesterol in all diets. Rats were fed for 30 days with 6 rats/diet. Isolated rat platelets were assayed for FA composition. Resting and thrombin-stimulated platelet [Ca++]i and thrombin-stimulated platelet TX synthesis were measured in the presence or absence of extracellular calcium and aspirin, ouabain, or nifedipine. The percentage linoleic acid in platelet FA rose linearly with increasing dietary linoleate. No measure of [Ca++]i or TX synthesis was changed by dietary linoleate; indicating that platelet [Ca++]i is not modified by platelet FA composition changed by differing

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