Abstract
A number of studies have investigated the roles of lipid peroxidation/ anti-oxidative balance as risk factors of prostate cancer. However, no study has yet to relate these factors with dietary habits of individuals in this environment. The objective of this study was to assess the role of lipid peroxidation and its relationship with vitamin D, calcium and dietary habits in individuals with prostate cancer. A total of sixty four (64) male participants (32 patients and 32 age-matched apparently healthy individuals as control) were recruited. Blood samples were analyzed for Malondialdehyde (MDA), Total antioxidant status (TAS), Calcium and Albumin spectrophotometrically; Prostate specific antigen (PSA) using immune radiometric assay; and Vitamin D by high performance liquid chromatography. Participants with prostate cancer had a significantly higher (p? 0.05) mean plasma level of MDA and PSA but lower TAS and vitamin D when compared with the control group. The plasma levels of MDA had a significant positive correlation with plasma PSA while negative with TAS in both groups. A significant proportion of the study participants that consumed dairy and smoked food regularly had a higher mean plasma level of MDA when compared with those that did not regularly as well as the control. This study has provided support for the hypothesis that lipid peroxidation and oxidative stress is associated with prostate cancer. A peculiar relationship exists between dairy and smoked food in prostate cancer which may be linked with increased lipid peroxidation.
Highlights
Prostate cancer is the most common male cancer in the developed world, second only to lung cancer worldwide, and is the sixth most common cause of cancer death among men [1]
One of the common features associated with cancer cells is increased reactive oxygen species generation and most cancer cells exhibit elevated oxidative stress with increased metabolic activity and production of ROS [7]
From an earlier study we suggested that latitudes, and older age all appeared to be positively the reason for which there was no significant correlated with greater risk of prostate cancer as well difference in the level of total antioxidant status was as vitamin D deficiency
Summary
Prostate cancer is the most common male cancer in the developed world, second only to lung cancer worldwide, and is the sixth most common cause of cancer death among men [1]. It has become the number one cancer in men with increasing incidence and morbidity in men of black African ancestry [2]. In Nigeria, one of the earliest epidemiological studies done was by Nkposong and Lawani (1973) [4] from the University College Hospital, Ibadan, who reported a low but increasing incidence of prostate cancer. One of the common features associated with cancer cells is increased reactive oxygen species generation and most cancer cells exhibit elevated oxidative stress with increased metabolic activity and production of ROS [7]
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