Abstract
1. 1. To determine which dietary components cause a restoration of disaggregated liver polysomes from fasted rats, polysome profiles from the livers of rats which had been fasted or fasted and refed diets of glucose or fat were prepared and evaluated. To investigate a possible mechanism through which dietary components act, polysome profiles on alloxan-diabetic and insulin-treated rats were prepared and analyzed. 2. 2. The gradual disaggregation of liver polysomes caused by fasting is virtually complete in 48 h. Ten h after refeeding glucose the polysome profiles of 60-h fasted rats are restored. Refeeding isocaloric amounts of fat to fasted rats is without effect. 3. 3. Production of experimental diabetes with alloxan is accompanied by a gradual disaggregation of the liver polysomes. Intraperitoneal administration of insulin restores the polysomes of an alloxan-diabetic rat within 1 h. 4. 4. Administration of insulin to fasted or fat-refed animals is without effect. 5. 5. The findings reported here appear to be unrelated to the reported effects of amino acid supply on liver polysome profiles. 6. 6. Insulin, in concert with glucose, has a rapid effect on the liver resulting in changes in the polysome profile.
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