Abstract
Abstract The ring-opening aldol-type reaction of 2-methoxy-2-(trimethylsiloxy)cyclobutanecarboxylic esters with aldehydes smoothly proceeded in the presence of a Lewis acid. Subsequent treatment of the crude products with a catalytic amount of p-TsOH gave cis-4,5-substituted δ-lactones in good yields with high diastereoselectivity. Similar reactions with unsymmetrical ketones also gave δ-lactones in good yields with moderate diastereoselectivity.
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