Diagnostic Values of Some Immunological Markers in Patients With Urinary Tract Infection

Abstract

The study was carried out in Tikrit city from January 1st to July 1st 2015. These patients admitted to Sallah Al-Deen general hospital and primary health care centers in Tikrit city. The number of patients with Urinary tract infection was 300 patients whom their ages ranged from 2 months to 70 years. The control group included 100 individuals who appeared healthy with no history of UTI. A urine direct and indirect examination was held for all the patients and control. The result showed 70 % positive specimens in culture media. Most isolates were Staph. aureus with 25%. Staph. saprophyticus 24% , E. coli 16%, K. pneumoneae 5% . Pseudomonas aeruginosa, and Proteus Spp. and Citrobacter frundii were present in about 5% and 7%, respectively. A member of (yeast-like fungi) Candida Spp. was also found in the ear in about 11%. Blood analysis showed that there was a significant increase in WBC, ESR, neutrophil, and CRP in UTI patients compared to the control group. Serum cytokines showed that the mean level of serum IL-1 family (IL-1α and IL-1β), IL-6, and IL-8 in addition to TNF-α, all were significantly higher in UTI patients than in the control group. Also, results showed a significant increase in serum cytokines in UTI patients with gram-negative bacteria in comparison with gram-negative bacteria. Conclusion: A significant difference was found between patients with UTI and control group regarding some immunological markers. They are also can differentiate between gram-positive and negative UTI. How to cite this article: Miranda, F.C., Kamath, K.K. and Shabaraya, A.R. (2019). Diagnostic Values of Some Immunological Markers in Patients With Urinary Tract Infection. International Journal of Drug Delivery Technology, 9(4): 635-639. Source of support: Nil. Conflict of interest: None.