Composition and drug resistance of pathogens causing complicated urinary tract infections

Abstract

Objectives To investigate the composition and drug resistance of pathogens causing the complicated urinary tract infections so as to provide guidance for reasonable use of antibiotics. Methods A retrospective analysis of clinical data and drug sensitivity test results of 108 patients with complicated urinary tract infections were made. Results 108 cases were detected in 325 urine samples of pathogens, including 218 strains of Gram–negative, coccus (67.08%), 62 strains of Gram–positive coccus (19.08%), 45 of the fungus(13.85%); Gram–negative strains of Escherichia coli accounted for 30.15%, followed by Pseudomonas aeruginosa (16.00%), Enterobacter cloacae (9.23%) and Klebsiella neumonia (7.69%).62 strains of Gram–positive coccus, staphylococcus aureus (7.08%), Enterococcus faecalis (5.54%) and urinary enterococci (4.92%) were commonly observed. The drug resistance rate of Gram–negative bacteria and positive bacteria to cephalosporins, penicillins, quinolones and gentamicin was as high as 50%, and the drug resistance rate of Gram–negative bacteria to meropenem and imipenem was less than 20%.The drug resistance rate of Gram–positive bacteria to vancomycin, teicoplanin and linezolid was less than 10%, and there was highly sensitive. Conclusions The complicated urinary tract infections bacterial spectrum and drug resistance have undergone significant changes, susceptibility testing should be carried out to select high sensitivity antibacterial drug clinically, it should not use a conventional cephalosporins and quinolones for empirical medication. Key words: Urinary Tract Infections; Drug Tolerance