Diagnostic value of serum lipoprotein (a) and free fatty acid in patients with type 2 diabetic nephropathy

Abstract

Objective To investigate the clinical value of serum lipoprotein (a) and free fatty acid (FFA) in the diagnosis of type 2 diabetic nephropathy (DN). Methods From January to October of 2016, 120 cases with type 2 diabetes in the Second People's Hospital of Lianyungang were selected.According to urinary albumin creatinine ratio (UACR), the patients were divided into three groups: normal albuminuria group (NA), microalbuminuria group (MA) and macroalbuminuria group(LA). And 40 healthy subjects were selected as control group.The levels of serum lipoprotein (a) and FFA were measured, and the correlation was analyzed by Pearson analysis.Furthermore, the receiver operating curve was used to evaluate the positive diagnostic rate of DN. Results The levels of lipoprotein (a) in the NA, MA, LA and control group were (212.8±69.0)mg/L, (281.7±70.5)mg/L, (337.2±71.5)mg/L and (187.4±74.0)mg/L, respectively.The levels of lipoprotein (a) in the MA and LA groups were significantly higher than those in the NA and control groups(F=35.08, P<0.05). The levels of FFA in the four groups were (0.63±0.15)mmol/L, (0.84±0.13)mmol/L, (1.07±0.19)mmol/L and (0.47±0.10)mmol/L, respectively.The level of FFA in the DN group was higher than that of the control group, the difference was statistically significant (F=102.13, P<0.05), and increased with the progression of DN.Pearson correlation analysis showed that the serum lipoprotein (a) was positively correlated with FFA (r=0.64, P<0.05). The positive rates of serum lipoprotein (a) and FFA were 64.2% and 73.3% in early diagnosis of DN, the positive rate of combined detection was 84.2% (P<0.05). Conclusion Serum lipoprotein (a) and FFA levels are significantly increased in diabetic patients with renal injury.Both of them have important clinical value in early diagnosis of type 2 DN. Key words: Diabetic nephropathy; Lipoprotein (a); Free fatty acid