Abstract
Objective To investigate the diagnostic value of serum homocysteine in the diagnosis of colon cancer. Methods The performance rate method was used to detect the level of serum homocysteine(Hcy) in colon cancer group(50 cases) who were treated in Beijing Tiantan Hospital Affiliated to Capital Medical University from March 2011 to June 2016 and control group(50 cases). The expression of independent samples t test was used to analysis of the difference of the Hcy levels between the two groups.The ROC curve was used to evaluate the value of Hcy in diagnosis of colon cancer. Results The serum Hcy level in colon cancer group was (18.6±8.9) μmol/L, in healthy control group was (10.7±4.3) μmol/L, colon cancer group serum Hcy levels were significantly higher than those of healthy control group, there was significant difference(t=5.627, P<0.01). AUC of ROC curve was 0.775, cut-off value of 18.5 μmol/L, sensitivity was 0.50, specificity was 0.94, 95%CI was 0.682-0.868(P<0.01). Conclusion Serum Hcy can be used as a reference index of the diagnosis of colon cancer. Key words: Homocysteine; Colon cancer; Tumor marker; ROC curve
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
