Effect of HP infection on serum homocysteine level in patients with obstructive sleep apnea syndrome

Abstract

Objective To investigate the effect of HP infection on serum homocysteine (Hcy) level in patients with obstructive sleep apnea syndrome (OSAS). Methods From Sep. 2012 to Aug. 2016, 180 patients with OSAS treated at our hospital were taken as the research objects. 90 OSAS patients with HP infection (30 mild OSAS patients, 30 moderate, and 30 severe) were set as an observation group and the other 90 OSAS patients with no HP infection (30 cases mild OSAS patients, 30 moderate, and 30 severe) were set as control group. The Hcy levels in the two groups were determined by chemiluminescence immunoassay; and the changes of Hcy levels in the OSAS patients with HP infection before and after the treatment were investigated. Results The Hcy levels of the patients with mild, moderate, and severe OSAS in the observation group were (12.21±0.26) μmol/L, (15.73±0.38) μmol/L, and (19.15±0.50) μmol/L, which were all significantly higher than those in the control group [ (10.90±0.22) μmol/L, (13.55±0.44) μmol/L, and (16.23±0.61) μmol/L] (t=21.067, 20.538, and 20.277;P =0.000, 0.000, and 0.000). The Hcy level, AHI, and ESS score were (11.44±0.02) μmol/L, (21.22±7.65) times/h, and (2.09±0.33) after the treatment and were (17.35±0.19) μmol/L, (49.89±9.03) times/h, and (12.19±2.92) before the treatment in the observation group, with statistical differences (t =29.297, 22.981, and 18.825;P =0.000, 0.000, and 0.000). Conclusion The level of Hcy in OSAS patients with HP infection are higher than that in OSAS patients with no HP infection; therefore, in order to avoid HP infection and deterioration, attention should be paid to the treatment of such patients with anti-HP infection. Key words: HP infection; Obstructive sleep apnea syndrome; Serum homocysteine