Analysis on the value of serum microRNA-183 in the diagnosis of colon cancer

Abstract

Objective To study and analysis of the value of serum microRNA (miRNA, miR)-183 in the diagnosis of colon cancer. Methods 89 cases of the patients with colon cancer were selected as the case group, 50 healthy volunteers were selected as the control group. The serum expressions of miR-183, the carcinoembryonic antigen (CEA), the carbohydrate antigen-724 (CA-724) of the subjects in the two groups were detected and compared. Results The serum expressions of miR-183, CEA, CA-724 of the patients in the case group were significantly higher than those in the control group, the differences between the two groups were statistically significant (P=0.001). The serum expressions of miR-183, CEA, CA-724 of the patients at TNM Ⅲ-Ⅳ stage were significantly higher than those at TNMⅠ-Ⅱ stage. The serum expressions of miR-183, CEA, CA-724 of the patients with lymph node metastasis were significantly higher than those without lymph node metastasis. The difference was statistically significant (P=0.006). In the diagnosis of colon cancer, the area under the receiver operating characteristic curve (AUC) of serum miR-183 was the highest (0.958) and the 95% confidence interval (CI) was (0.931-0.985). In the diagnosis of early colon cancer, AUC of serum miR-183 was the highest (0.883) and the 95% CI was (0.809-0.956). Conclusion The patients colon with cancer patients show overexpression of serum miR-183. The level is related with the degrees of invasion and diffusion of the tumor, and can be used as the serum markers. in early diagnosis and evaluation of disease of colon cancer Key words: Serum; MicroRNA-183; Carcinoembryonic antigen; Carbohydrate antigen-724; Colon cancer; Eiagnosis