Development, Standardization and Evaluation of Antimicrobial Syrup

Abstract

Ayurveda states that it takes more than just herbs to accomplish a medicinal impact. Optimizing its composition as a combination of herbs in a certain ratio improves its medicinal impact while reducing toxicity. The purpose of this research was to make a polyherbal syrup using aqueous extracts of Azadirachta indica, Curcuma longa, Allium sativum, Ocimum tenuiflorum, and Punica granatum in varying proportions in order to provide such an intervention. The agar well diffusion technique was used to screen the formulation for antimicrobial and antifungal activity against various organisms, including Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus niger, which are representative of gram-positive and gram-negative bacteria, respectively. The syrup underwent review and standardization for multiple assessment criteria. Additionally, this formulation was subjected to an expedited stability test. Research demonstrated that the tested formulation outperformed the gold standard in terms of zone of inhibition. The formulation that has been produced meets all of the requirements, however, additional in-vitro and in-vivo investigations are needed to confirm its effectiveness.