Abstract
A mino acid-based surfactants constitute a class of cationic surfactants with excellent surface p roperties, wide biological activ ity, low potential to xicity. Essential structural factors for their antimicrobial activity include both the length of the fatty residue and the presence of the protonated guanidine function. These features and the use of natural raw materials such as Arginine and fatty acids for their synthesis, make them interesting candidates as preservatives and antiseptics in pharmaceutical, food and cosmetic fo rmulat ions. The present work describes the synthesis (at lab scale), the physicochemical properties of long chain N α -acyl arginine ethyl esters with a chain of 8 and 9 carbon atoms. These compounds have been prepared by condensation of L-arg inine ethyl ester dihydrochloride with corresponding acyl chlorides in the presence of base. The basic charastristic properties such as physical appearance, structural identificat ion by IR/ H 1 NMR, water solubility at different pH and surface tension studies of the synthesized co mpounds are discussed. The Antimicrobial properties of the co mpounds of invention are studied by determin ing their M inimu m inhibitory concentration for different microorganisms.
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