Abstract

In the present paper, one-pot green syntheses of novel hydrophilic and superparamagnetic molecularly imprinted polymers (MMIPs) for the cleanup and extraction of hydrochlorothiazide (HCT) in human urine are described. The MMIPs were prepared via a sol–gel process using Fe3O4 magnetite as a magnetic component, HCT as a template, tetraethyl orthosilicate (TEOS) as the cross-linker, and 3-aminopropyl trimethoxysilane (APTMS) as the functionalized monomer, which could simplify the imprinting process. During the synthesis process, a surfactant was especially used to graft the silica-imprinted nanoparticles. The key step of this research is mild working temperature without consuming any organic solvent during the synthesis of MMIPs in addition to its ability for efficient and highly selective enrichment of HCT in complicated human urine. The morphology, structure, and magnetic properties of the MMIPs were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier tra...

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