Abstract
Surgery, particularly open surgery, is known to cause tissue/organ adhesion during healing. These adhesions occur through contact between the surgical treatment site and other organ, bone, or abdominal sites. Fibrous bands can form in unnecessary contact areas and cause various complications. Consequently, film- and gel-type anti-adhesion agents have been developed. The development of sustained drug delivery systems is very important for disease treatment and prevention. In this study, the drug release behavior was controlled by crosslinking lidocaine-loaded alginate/carboxymethyl cellulose (CMC)/polyethylene oxide (PEO) nanofiber films prepared by electrospinning. Lidocaine is mainly used as an anesthetic and is known to have anti-adhesion effects. Our results show that drug release is regulated by the crosslinking degree of the lidocaine-loaded alginate/CMC/PEO film. The drug release behavior was confirmed by HPLC, and, as a result, an excellent anti-adhesion barrier was developed that can be applied to treat patients in the medical field.
Highlights
Most abdominal operations cause unnecessary tissue adhesion during the tissue healing process [1], which can lead to various complications [2]
The alginate/carboxymethyl cellulose (CMC)/polyethylene oxide (PEO) nanofiber films fabricated by electrospinning were characterized by scanning electron microscopy (SEM)
It was confirmed that the 9% alginate/CMC/PEO
Summary
Most abdominal operations cause unnecessary tissue adhesion during the tissue healing process [1], which can lead to various complications [2]. Various formulations of film or gel anti-adhesion agents are used to prevent tissue adhesion after abdominal operations [3]. Scheme 1 shows the process of postsurgical tissue/organ adhesion and the role of the anti-adhesion barrier. Medical sutures or medical glues are commonly used to fix the anti-adhesion agent at the surgical site [7,8]. Suturing or glues can act as an additional stimulus to the surgical site and cause complications such as inflammation, which can potentially become another factor that causes adhesion [8,9,10]. Anti-adhesion barriers are usually applied without additional fixation in surgery
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