Abstract
A simple, precise, and accurate high-performance thin-layer chromatography (HPTLC) method for the simultaneous determination of propranolol hydrochloride (PRP) and flunarizine dihydrochloride (FLU) in their combined tablet dosage form has been developed and validated. Propranolol hydrochloride and flunarizine dihydrochloride from the formulation were separated on silica gel 60 GF254 HPTLC plates with solutions in the proportion of methanol-chloroform-toluene-GAA (3:7.5:7.5:0.3 v/v) as mobile phase. Densitometric quantification was performed at 260 nm. Well-resolved bands were obtained with RF values 0.35 and 0.64 for propranolol hydrochloride and flunarizine dihydrochloride, respectively. The method was validated for precision, accuracy, and specificity. The calibration curve was found to be linear in the concentration range of 3000–15,000 ng band−1 and 750–3700 ng band−1 of PRP and FLU respectively. Correlation co-efficient by area is 0.9991 and 0.9995 for PRP and FLU, respectively. The method is selecti...
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