Development and Evaluation of Polyherbal Gel for Treatment of Diabetic Neuropathy

Abstract

Diabetic neuropathy is a prevalent and painful issue of diabetes mellitus, impacting a large number of people with both type 1 and 2 diabetes. Herbal formulations are found to be effective and have fewer side effects. The study aimed to create a topical polyherbal gel using ethanolic extracts and to evaluate polyherbal gel. Ethanolic extract of Curcuma longa rhizomes and Gingko biloba leaves were obtained and used to prepare different formulations of polyherbal gels using Carbopol 940 and other excipients. The developed compositions were assessed using a range of gel evaluation standards, including physical examination pH, viscosity measurement, spreadability. The in-vitro permeation study is derived from the Franz diffusion. The evaluation shows ideal results for polyherbal gel. The pH of the polyherbal gel was observed to be between 6.22 and 6.51, which is considered suitable for topical application. The polyherbal gel formulations showed ideal viscosity range and spreadability. Among the four formulations, the PG3 formulation was found to be stable.