Development and evaluation of ketoprofen sustained delivery system using Neem Gum

Abstract

Background: The main objective of this work is to formulate a sustained release matrix tablets using neem gum. Ketoprofen was selected as a model drug due to the low biological half life, it requires frequent administration. Hence sustained dosage forms are formulated to reduce the dosage frequency. Methods: Ketoprofen matrix tablets were formulated by employing neem gum as a release rate retardant material and used in 10%, 20%, 30%, and 40% Concentration levels. Wet granulation method was used to develop sustained release tablets. Results: Tablet was evaluated in terms of flow properties of blended powders and the average weight, drug content hardness, in vitro dissolution studies and fourier transformation-infrared spectroscopy (FT-IR) were determined. Drug release was evaluated with zero and the first order for release kinetics, Higuchi, Korsmeyer peppas models for the release mechanism. The hardness of the tablets ranged from 5 to 7 Kg/cm2 and the friability values were less than 1% indicating that the matrix tablets were compact and hard. All the formulations satisfied the content of the drug as they contained 99.1 to 100.8% of Ketoprofen, KNS3 released 99.2 of drug in 12 hours and KNS4 released 90.13% of drug in 12 hours using neem gum and This data reveals that drug release follows fickian diffusion mechanism Peppas model. Conclusion: The present study could establish the suitability of neem gum as Controlled released (CR) polymer in the design of matrix tablets.