Preparation and Characterisation of Sustained Released Dosage Form for Ketoprofen using Natural Gums

Abstract

Objective: The major objective of this work is to formulate a sustained launch matrix drugs the use of cashew and neem gum. Ketoprofen turned into decided on as a version drug because of the low half-life. Hencesustained dosage forms are formulated to lessen the dosage frequency. Methods: Ketoprofen matrix tablets were formulated by employing cashew gum and neem gum as a release rate retardant material and used in10%, 20%, 30% and 40% Concentration levels. Wet granulation method was used to develop sustained release tablets. Tablet was evaluated in terms of flow properties of blended powders and the average weight, drugcontent hardness, in vitro dissolution studies and fourier transformationinfrared spectroscopyn (FT-IR) were determined. Drug release was evaluated with zero and the first order for release kinetics, Higuchi, Korsmeyerpeppas models for the release mechanism. Results: The hardness of the tablets ranged from 5.5 to 6.8 Kg/cm2 and the friability values were less than 1% indicating that the matrix tablets were compact and hard. All theformulations satisfied the content of the drug as they contained 99.1 to 100.8 % of ketoprofen, KCS8 released 99.2 of drug in 12 hrs and considered as optimized formulas. KCS8 formulation has shown drug release byzero order kinetics. This data reveals that drug release follows fickian diffusion mechanism Peppas model. Conclusion: The present study could establish the suitability of neem gum, cashew gum as Controlled released(CR) polymer in the design of matrix tablets.