Development and Characterization of Lornoxicam loaded microsponge gel for Rheumatoid arthritis

Abstract

Transdermal delivery, a successful novel approach aimed at achieving systematically active level of drug. The drug lornoxicam is a non-steroidal anti-inflammatory drug bearing analgesic, anti-inflammatory, and antipyretic property. The micro sponge technology used to facilitate the controlled release of active drug into the skin in order to reduce the systematic exposure and minimize local cutaneous reactions of active drugs. The main objective of this work was to design and evaluate the gel formation of microsponge entrapped lornoxicam to increase the effectiveness of the treatment. The microsponges were prepared by quasi emulsion solvent diffusion method. The internal phase consisting eudragit RS-100 dissolved in dichloromethane, drug is slowly added to polymer solution with continuous stirring for 4 h, and then mixture was filtered to separate the microsponges. Microsponges was characterized by parameters like scanning electron microscopy, drug content, particle size analysis, compatibility studies using differential scanning calorimetry. Microsponge-loaded gel was characterized by physical parameters of gel, measurement of PH, viscosity study, Drug content study, in-vitro release studies using Franz diffusion cell, cellophane membrane. The prepared gel were subjected to different kinetics models showed that the release data, rheological study, thixotrophy analysis, FT-IR spectral analysis. The release profile of the lornoxicam in the form of microsponges gel was compared with that of pure lornoxicam gel. From the results it can be concluded that microsponges gel LMSG-2 formulation shows drug release in a controlled manner could sustain the drug release over period of 8 hours.