Abstract
Phytosomes, a novel drug delivery system, have gained attention for their potential in the treatment of polycystic ovarian syndrome (PCOS). Polycystic ovaries, unpredictable menstrual cycles, and hormonal imbalances are the hallmarks of PCOS, a frequent endocrine disorder affecting women of reproductive age. The main aim is to prepare and evaluate phytosomes for the treatment of PCOS. The materials used were guggul from Commiphora mukul, berberine from Berberis vulgaris and green tea from Camellia sinensis. All the phytosomal formulations are prepared in ratios and further evaluated. Phytosomal screening confirms the presence of required phytosomes like alkaloids, tannins and saponins that are effective in treating PCOS. Fourier-transform infrared spectroscopy (FTIR) evaluation was performed and ex-vivo and sub-acute toxicity evaluation confirms that formulation, PY4: Soy lecithin at a 3:1 extract ratio exhibited a greater release profile without any harm. As per the findings of this study, employing optimized phytosome-based medication delivery as bio-enhancers may enhance the bioavailability of herbal extract.
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