Determination of Stability Constant of Flurosubstituted Chlconemines for its Medicinal Efficiency

Abstract

The good activity of drug is depending upon its stability constant i.e. proton ligand stability constant and metal ligand stability constant. If the stability constant is fairly very good then it should use as a good and effective medicine .In content to this in present work the proton ligand stability constant and metal ligand stability constant of fluro substituted chalconeimines L5 = 2-Hydroxy naphthalene 4-dimethyl aniline 4- fluro chalconeimine [FN] are studied with highly reactive transition metal like (Cu (II), Co(II),Cr(II) and Fe(III)). The 70% dioxane water solvent system used in the present investigation. The presence of –OH group confirmed by using of 0.1 M ionic strength. The transition metal (Cu (II),Co (II),Cr(II)and Fe(III)) used and the ligand form 1:1 and 1:2 complex with all values of log k1 and log k2 positive.