Abstract
Background:A drug sensor (salicylic acid, in this case) was designed and made up of this research. The senor was made by modification of paste electrode (MPE) with CuO-SWCNTs and 1-hexyl-3-methylimidazolium chloride (HMICl). The MPE/CuO-SWCNTs/HMICl showed catalytic activity for the oxidation signal of salicylic acid in phosphate buffer solution.Methods:Electrochemical methods were used as a powerful strategy for the determination of salicylic acid in pharmaceutical samples. Aiming at this goal, carbon paste electrode was amplified with conductive materials and used as a working electrode.Results:The MPE/CuO-SWCNTs/HMICl was used for the determination of salicylic acid in the concentration range of 1.0 nM – 230 µM using differential pulse voltammetric (DPV) method. At pH=7.0, as optimum condition, the MPE/CuOSWCNTs/HMICl displayed a high-quality ability for the determination of salicylic acid in urine, pharmaceutical serum, and water samples.Conclusion:The MPE/CuO-SWCNTs/HMICl was successfully used as a new and high performance working electrode for the determination of salicylic acid at a nanomolar level and in real samples.
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