Abstract
Methods for determination of oxazepam in pharmaceutical formulation by derivative ultraviolet (UV) spectrophotometry as well as high-performance thin-layer chromatography (HPTLC) UV densitometry were described. For UV-derivative spectrophotometry, some derivatives and wavelengths may be recommended for routine quality control of the drug of interest. On the other hand, HPTLC provided good results, but only when the calibration curve was estimated using nonlinear regression analysis. The HPTLC method was developed with silica F254 plates, a mobile phase of benzene/ethanol (5:1, v/v), and densitometric detection at 204 nm receiving R f = 0.47. Developed methods were validated and found to be sufficiently precise and reproducible for established conditions.
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