Abstract
Abstract Combining non-sedating antihistamines (NSAs) with montelukast (MON) has been found to significantly enhance the therapeutic efficacy against daytime and composite nasal symptoms, including rhinorrhea, sneezing, and itching. This article reviews the current analytical methods employed for the identification and quantitative determination of MON in combination with NSAs in various marketed formulations. The most commonly used methods for the determination of MON and NSAs in combination are chromatographic methods (high-performance liquid chromatography [HPLC] and thin-layer chromatography) and spectrometry methods (spectrofluorometry and spectrophotometry). Recent preferences in the analysis of MON and NSAs in combination samples prove the primacy of HPLC (61%) and confirm the general trends moving toward more sensitive methods, with a higher resolution potential, consumption of small quantities of samples and reagents, and requiring less analysis time.
Published Version
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