Abstract
Objective To establish content determination method of amoxicillin and clavulanate potassium. Methods The parameters of detection was as followed: HPLC column: Hypersil BDS C18 (4.6× 200 mum, 5μm); mobile phase: sodium dodecylsulfate solution - acetonitrile (92:8); flow: 1.0ml/min;chromatographic temperature: 25C; detection wavelength: 220 nm; injection volume: 10 μ 1. ResultsThe linear range of clavulanate potassium was good at 4.05 - 40.48 μ g ( r = 0.9999 ) and the average recovery was 99.7% (RSD = 2.1%); The linear range of amoxicillin was good at 1.15 - 11.53 μ g( r = 0.9999 )and the average recovery was 99.6% (RSD = 0.7%). Conclusions This method is accurate and easy to use, with better recovery and higher separation. It can be used for quality control of the related preparations. Key words: Clavulanate potassium; Amoxicillin; HPLC
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