The clinical observation of improved sequential therapies for Helicobacter pylori-positive peptic ulcer

Abstract

Objective To observe the clinical efficacy and safety of ten-days sequential therapy consisted of omeprazole,colloidal bismuth subcitrate potassium,amoxicillin and clavulanate potassium,levofloxacin on Helicobacter pylori (Hp)-positive peptic ulcer.Methods Totally 117 Helicobacter pylori-infected patients with peptic ulcer diagnosed by gastroscopy were enrolled.The patients were randomized divided into treatment group (59 cases) who received omeprazole 20 mg,2 times one day,amoxicillin and clavulanate potassium 457 mg,2 times one day,after meal colloidal bismuth subcitrate potassium 200 mg,2 times one day,for the first five days,and followed by omeprazole 20 mg,2 times one day,levofloxacin 200 mg,2 times one day,for the last five days;the control group (58 cases) treated with omeprazole 20 mg,2 times one day,amoxicillin and clavulanate potassium 457 mg,2 times one day,after meals clarithromycin 500 mg,2 times one day,for ten days,4 weeks underwent 13C-urea breath test.Results The treatment group 13C urea breath test negative rate was 94.9%,negative control group was 70.6%,compared two groups of Hp negative rate was significant difference (P＜0.05).Conclusions The modified sequential therapy of Hp-positive peptic ulcer with high eradication rates and safe is good. Key words: Sequential therapy; Helicobacter pylori; Peptic ulcer