Abstract
The solubility data of linezolid form II in five pure solvents (water, methanol, ethanol, 1-propanol, 2-propanol) and a binary (water + methanol) solvent were determined among the temperature range from 283.15 K to 318.15 K under atmospheric pressure. The results indicated that the solubility increased with the temperature increasing. Seven thermodynamic models were used here to correlate the experimental solubility data. Through the comparison of the experimental data in pure solvents with the calculated results, we found that the modified Apelblat equation fit the experimental data best. Furthermore, the density functional theory (DFT) calculations showed that the solubility in different solvents related to the interaction strength between the linezolid and the solvent molecules. Finally, the molar enthalpy change, molar entropy change and molar Gibbs free energy change of dissolution of linezolid in the different solvents were also calculated by van't Hoff equation in this paper.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
