Abstract
In this work, solubility data of ceftezole in seven pure solvents and two binary solvent systems were experimentally measured via a static gravimetric method in the temperature range from 278.15 K to 313.15 K under atmospheric pressure. The results indicated that the solubility of ceftezole in all the selected pure and binary solvent systems increased with the rising of temperature. It was also found that the solubility order of ceftezole in the seven mono-solvents was generally ranked as: water < methanol < ethanol < isopropanol < acetonitrile < ethyl acetate < acetone. The Apelblat model and the NRTL model were used to correlate the experimental solubility data of ceftezole in pure solvents, and the modified Apelblat equation, the CNIBS/R-K model and the combined version of the Jouyban–Acree were applied for binary solvents. The calculation results agreed fairly well with the experimental data. Finally, the mixing and dissolution thermodynamic properties of ceftezole in all the tested solvents were calculated based on the NRTL model and the experimental solubility data.
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