Abstract
Objective To investigate the changes of pulmonary function in children with asthma and its clinical significance. Methods Asthmatic children treated in our hospital from February 2014 to November 2015 accepted treatment were selected as the observation object, according to the extent of the disease, which were divided into acute and chronic persistent period.At the same time, total 40 cases of healthy children as control group, three groups were given the tidal breathing method for detection of pulmonary function.The changes of lung function indexes were observed in three groups.The difference of serum inflammatory cytokines levels between the three groups was compared, and the correlation between the lung function indexes and the levels of inflammatory cytokines and the quality of life were analyzed. Results The acute attack group were inspiratory time (TI), (TE) and expiratory time peak tidal expiratory flow (TPTEF) method of tidal breathing lung function index is lower than the control group, RR was higher than the control group, and three groups of inspiratory flow (MIF), the average expiratory flow rate (MEF) and peak inspiratory tidal velocity (PTEF) levels have no significant difference.The levels of inflammatory cytokines such as interleukin-6 (IL-6), IL-10 and tumor necrosis factor alpha (TNF-α) in the three groups were higher than that in the acute episode group, chronic persistent group and control group, the difference was statistically significant (F=9.689, 25.364, 42.025, 48.952, 38.158, P<0.001). The lung function indexes were negatively correlated with the inflammatory cytokines in the patients (r=-0.398, -0.412, -0.432, -0.406, -0.382, P<0.05), and were postived correlated with life queality (r=-0.398, -0.412, -0.432, -0.406, -0.382, P<0.05). Conclusions Pulmonary function test has good application value in the diagnosis of children with asthma, and is closely related to the laboratory indexes of the children. Key words: Tidal breathing; Asthma; Cytokines; Correlation analysis
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