The curative effect of inhaled high dose of budesonide in the treatment of children with severe asthma and its effect on serum cytokine levels

Abstract

Objective To investigate the curative effect of inhaled high dose of budesonide in the treatment of children with severe asthma and its effect on serum cytokine levels. Methods 86 children with severe asthma in our hospital from March 2015 to April 2016 were divided into two groups according to the random number table, 43 cases in each group. The control group was given small dose of budesonide, while the study group was given high dose of budesonide. Compared the curative effect, disappearance time of clinical symptoms, the levels of serum cytokine and lung function index [forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), maximal mid-expiratory flow (MMEF)] before and after treatment between the two groups, and analyzed the occurrence of adverse reactions. Results The effective rate of the study group was 90.70%, significantly higher than 74.42% of the control group, and the disappearance time of clinical symptoms of the study group was less than that of the control group (P 0.05); all the levels of the study group were significantly lower than those of the control group after treatment (P 0.05); all the levels of the study group were significantly better than those of the control group after treatment (P 0.05). Conclusions Inhaled high dose of budesonide has good curative effect in the treatment of children with severe asthma, which can reduce symptoms disappearance time, improve the levels of serum cytokines and lung function in children, and doesn't increase the incidence of adverse reactions at the same time. Key words: High dose; Budesonide; Severe asthma; Serum cytokine